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Selecta Biosciences and IGAN Biosciences Enter into Research License and Option Agreement to Study Selecta’s ImmTOR™ Immune Tolerance Platform in Combination with IGAN’s IgA Protease for the Treatment of IgA Nephropathy
Application of ImmTOR™ plus IGAN’s IgA protease to target immunoglobulin A (IgA) deposition, the critical event leading to IgA Nephropathy (IgAN)
Selecta’s IgA nephropathy program builds upon SEL-212, which has demonstrated ImmTOR™ effective at tolerizing a highly immunogenic therapeutic enzyme
Investigational New Drug (IND) application expected in Q4 2021
Previous studies in animal models conducted at independent laboratories established the ability of IGAN’s IgA protease to remove injurious IgA from kidneys and improve markers of renal dysfunction. These results suggest that it is an excellent candidate to decrease the rate of disease progression and possibly even reverse the disease. The barrier to IgA protease commercialization is the bacterial origin of the protease, which makes it immunogenic. Selecta’s proprietary immune tolerance platform, ImmTOR, has shown in clinical studies the ability to mitigate the formation of anti-drug antibodies (ADAs) to immunogenic enzymes. This has been demonstrated with its phase 3 lead product candidate, SEL-212, which is a combination of ImmTOR and pegadricase, an immunogenic proprietary pegylated uricase for the treatment of chronic refractory gout.
“We are excited to build on our learnings from SEL-212 in combining an immunogenic enzyme with our ImmTOR platform to develop a product candidate for IgA nephropathy,” said
“IGAN is pleased to enter into this agreement with
IgA Nephropathy is characterized by deposition of galactose-deficient IgA1 immunoglobulin in the glomerular mesangium and is a leading contributor to development of chronic kidney disease and renal failure. Genetic or environmental causes that form this abnormal IgA1 and its accumulation in the kidney can result in the development of IgAN. Hypertension, proteinuria and decreased eGFR at the time of diagnosis are associated with poor prognosis. It can result in incremental loss of renal function and results in end stage renal disease (ESRD) in approximately 30 - 40% of patients. There are no approved therapies for the treatment of IgAN.
Under the terms of the research license and option agreement,
About Selecta Biosciences, Inc.
About IGAN Biosciences
IGAN Biosciences is a private biotechnology company advancing IgA protease treatment for IgA deposition diseases. Its founders discovered and characterized IgA proteases during more than forty years of research conducted at
This press release, contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding Selecta’s plan to participate in upcoming investor conferences. All such forward-looking statements are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. Such risks and uncertainties include but are not limited to the company’s plans to exercise its option to enter into a licensing agreement, preclinical research and development activities related to IGAN’s IgA Protease, the ability of the IgA Protease to remove injurious IgA from kidneys and improve markers of renal dysfunction, the company’s plans to develop a product candidate to treat IgA Nephropathy or other autoimmune indications, the material impact, if any, of the COVID-19 outbreak on the Company’s operations, including supply chain and clinical trials, other COVID-19 related risks and those set forth in the “Risk Factors” section of Selecta’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission, or SEC, for the quarter ended March 31, 2020, and in other filings that Selecta makes with the SEC. In addition, any forward-looking statements included in this press release represent Selecta’s views only as of the date of its publication and should not be relied upon as representing its views as of any subsequent date. Selecta specifically disclaims any obligation to update any forward-looking statements included in this press release.
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Source: Selecta Biosciences, Inc.